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Permanent, Interim, and Fractional Executives. A Guide for Biotech Founders and Boards.
The terms permanent, interim, and fractional executive are used inconsistently across Europe, the UK, and the US. Founders and boards making leadership decisions need to understand what each model actually means, when it applies, and how it interacts with the separate legal layer of statutory officer responsibility. This guide is the foundation I built over fifteen years of placing executives across these models. It is the same definitional framework I use in every first conversation about an engagement structure.
This guide is provided for general information only. It is not legal, tax, or compliance advice. Statutory officer responsibility, employment law, and contract structures vary by jurisdiction and individual circumstances. Always consult qualified legal and tax advisors before structuring an executive engagement.
The four dimensions that define every executive engagement
Most confusion comes from collapsing four separate dimensions into one label. Permanent, interim, and fractional are not competing categories. They describe one dimension of an engagement. There are three more.
Each engagement is defined by four independent questions:
- Duration. Is the role permanent or temporary?
- Time commitment. Is the role full-time or part-time?
- Contract model. Is the person employed by the company or self-employed?
- Legal responsibility. Does the person hold statutory officer responsibility, with formal legal duties and personal liability?
Once these four are separated, the terminology stops being confusing. A person can be a permanent full-time CFO without statutory appointment. Or an interim Managing Director who is a statutory officer for six months. Or a fractional CFO who is employed part-time. The labels describe different dimensions, not different types of person.
Permanent executives model
What a permanent executive is
A permanent executive is a senior leader hired by the company for an open-ended, long-term role. They are expected to become part of the long-term leadership team. The role is built to scale with the company, not to bridge a gap.
Typical permanent C-level roles include Chief Executive Officer, Chief Financial Officer, Chief Operating Officer, Chief Business Officer, Chief Commercial Officer, Chief Medical Officer, Chief Scientific Officer, Chief Technical Officer, Chief People Officer, General Manager, and Managing Director.
Contract and time structure
Permanent executives are usually employed directly by the company. Most are full-time. Part-time permanent roles exist, especially in early-stage biotech, family-owned companies, and subsidiaries where the long-term function does not yet justify a full-time hire. A permanent part-time CFO three days per week is a valid structure when the relationship is ongoing and not designed as a temporary bridge.
When to hire a permanent executive
Permanent executives are the right choice when the company needs long-term leadership, cultural integration, and continuity. Common triggers include preparation for a financing round, scaling after an investment, building or replacing a leadership team, professionalizing a function, international expansion, IPO readiness, or M&A preparation. The cost of a wrong permanent hire is high. The cost of an unfilled permanent role at the right moment is higher.
Interim executives model
What an interim executive is
An interim executive is a senior leader brought in for a temporary period to provide immediate leadership. The purpose is usually to stabilize a function, fill a gap, manage a transition, or deliver a specific outcome.
Typical interim mandates include Interim CEO, Interim CFO, Interim COO, Interim CMO, Interim Managing Director, Interim General Manager, and Interim Transformation Lead. The defining feature is not the contract model. The defining feature is that the role is temporary.
Contract and time structure
Interim executives are often self-employed or engaged through their own limited company. They can also be employed on a fixed-term contract, seconded through an interim provider, or engaged through a consulting firm. Interim does not mean self-employed by definition. Interim means temporary.
Most interim roles are full-time or near full-time, especially in crisis, transformation, or executive vacancy situations. Part-time interim mandates exist for less acute situations: an interim CFO three days per week during a fundraising process, for example.
When to hire an interim executive
Interim executives are the right choice when there is urgency. A CFO leaves three months before a financing round. A CMO is needed during a clinical readout. A CEO is required between cycles. A subsidiary needs a Managing Director after a sudden departure. The board needs operational leadership during a restructuring. In each case, the alternative is months of decision drag while a permanent search runs. Interim is the structural answer to time-critical leadership gaps.
I place interim at C-level in six days. No other firm in Europe does this credibly.
Fractional executives
What a fractional executive is
A fractional executive is a senior leader who works for a company on a part-time basis. The company receives executive-level expertise for a fraction of the time, cost, and commitment of a full-time hire.
Typical fractional roles include Fractional CFO, Fractional COO, Fractional CMO, Fractional CBO, Fractional Chief of Staff, and Fractional Operating Partner. The defining feature is part-time engagement.
Contract and time structure
Fractional executives are often self-employed and engaged on a monthly retainer. They can also be employed part-time, especially through holding companies, venture builders, or portfolio support structures. Common time models include one day per week, two days per week, a fixed number of days per month, or flexible support around key events such as board meetings, financing rounds, or audits.
When to hire a fractional executive
Fractional executives are the right choice when the company needs senior expertise but cannot justify a full-time hire. A seed-stage biotech needs CFO-level support for runway management and investor reporting, two days per month. A founder needs an experienced COO one day per week to professionalize operations before reaching scale. A pre-Series-B company needs a CBO to support partnering discussions before a full-time business development leader is affordable.
The risk to manage with fractional is scope: too little time, unclear authority, or the gap between strategic input and operational follow-through. The mandate must be defined precisely.
Statutory officer responsibility - The separate legal layer
The biggest source of confusion in executive engagements is the difference between job title and legal appointment. A person may be called CEO, CFO, or Managing Director in a commercial sense. That title does not automatically make them a statutory officer of the company.
A statutory officer is formally appointed to a legally recognized corporate role. The exact form depends on jurisdiction:
- Germany and Austria: Geschäftsführer of a GmbH, Vorstand of an AG
- United Kingdom: Director of a limited company
- United States: Officer or Director of a corporation
- Europe broadly: Statutory representative of a local subsidiary
A statutory officer has legal duties that go beyond an ordinary employment or consulting relationship: fiduciary duties, duty of care, duty of loyalty, legal representation authority, tax and compliance obligations, insolvency-related duties, financial reporting duties, and potential personal liability.
his distinction matters in every executive engagement. Permanent, interim, and fractional executives can each be appointed as statutory officers, or not. The choice is a legal and governance decision, not just an operational one.
Board-level versus board member
Board-level and board member are not the same thing. The distinction matters especially in cross-border engagements.
Board-level describes seniority. An executive senior enough to interact with the board, report to investors, or operate at executive committee level is board-level. A CFO can be board-level by virtue of seniority, without being a member of any board.
Board member describes a formal governance role: member of the Board of Directors in the US or UK, member of the Management Board or Supervisory Board in Germany or Austria, Executive Board Member of an AG, Non-Executive Director, or Advisory Board member. These roles carry specific governance, fiduciary, and oversight responsibilities.
Statutory officer is a third, separate concept: a person formally appointed to a legally recognized corporate office, with personal legal duties and potential liability.
The three overlap in some jurisdictions and remain separate in others. Clarifying which of the three a candidate is being hired into is essential, especially in cross-border searches between Europe, the UK, and the US.
How to chose the right model
The right model depends on five questions.
- Is the need long-term or temporary? Long-term suggests permanent. Temporary suggests interim. Ongoing but part-time suggests fractional.
- Is the role full-time or part-time? If part-time, fractional. If full-time and ongoing, permanent. If full-time and temporary, interim.
- Does the company need legal representation authority? If yes, the role must be structured with statutory officer responsibility. This affects contract type, insurance, indemnification, and liability exposure.
- Is speed more important than long-term cultural fit? Interim placements close in six days. Permanent searches close in under sixty days. Speed and fit are not in conflict, but the relative priority shapes the model.
- Does the company need execution, advice, or both? Some executives are mainly advisors. Others are hands-on operators. The mandate must match the model. A fractional CFO expected to provide full integration will disappoint. An interim CFO expected to be a long-term cultural anchor will also disappoint.

